2024

Meyer, H., Bossen, J., Janz, M., Müller, X., Künzel, S., Roeder, T. and Paululat, A. (2024). Combined transcriptome and proteome profiling reveal cell-type-specific functions of Drosophila garland and pericardial nephrocytes. Communications Biology 7:1424. doi: 10.1038/s42003-024-07062-z

Ratnavadivel, S., Dammeier, J., Gaertner, A., Szymanski de Toledo, M.A., Zenke, M., Gummert, J., Rasmussen, T.B., Klinke, N., Jürgens, K., Meyer, H., Paululat, A. and Milting, H. (2024) Generation of a TMEM43 knockout human induced pluripotent stem cell line (HDZi003-A-1) using CRISPR/Cas9. Stem Cell Research 76: 103354. doi: 0.1016/j.scr.2024.103354

2023

Meyer, C., Drechsler, M., Meyer, H. and Paululat, A. (2023) Differentiation and function of cardiac valves in the adult Drosophila heart. Journal of Experimental Biology (J Exp Biol) 226(13) doi: 10.1242/jeb.245839.

Buhr, A., Schiemann, R. and Meyer, H. (2023) Neprilysin 4: An essential peptidase with multifaceted physiological relevance. Biological Chemistry. DOI: 10.1515/hsz-2022-0286

Schiemann, R. and Meyer, H. (2023) Neprilysins. In “Handbook of Proteolytic Enzymes. Metallopeptidases.” 4th Ed., Rawlings, N. & Auld, D. (ed). ISBN: 978012823587

2022

Schiemann, R., Buhr, A., Cordes, E., Walter, S., Heinisch, J.J., Ferrero, P., Milting, H., Paululat, A. and Meyer, H. (2022) Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides. Nature Communications. 13(1): 4420. DOI: 10.1038/s41467-022-31974-1

Meyer, C., Breitsprecher, L., Bataille, L., Vincent, A.J.M., Drechsler, M., Meyer, H. and  Paululat, A. (2022) Formation and function of a highly specialised type of organelle in cardiac valve cells. Development. 149(19):dev200701. doi: 10.1242/dev.200701.

Klinke, N., Meyer, H., Ratnavadivel, S., Reinhardt, M., Heinisch, J.J., Malmendal, A., Milting, H. and Paululat, A. (2022) A Drosophila melanogaster model for TMEM43 related Arrhythmogenic right ventricular cardiomyopathy type 5. Cellular and Molecular Life Sciences (Cell Mol Life Sci), 79(8):444. DOI: 10.1007/s00018-022-04458-0

Santalla, M., Garcia, A., Mattiazzi, A., Valverde, C.A., Schiemann, R., Paululat, A., Hernandez, G., Meyer, H.* and Ferrero, P.* (2022) Interplay between SERCA, 4E-BP, and eIF4E in the Drosophila heart. PlosOne 17(5). doi: 10.1371/journal.pone.0267156. (*co-corresponding author)

2021

Meyer, H.*, Buhr, A., Callaerts, P., Schiemann, R., Wolfner, M.F. and Marygold, S.J.* (2021) Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. MicroPublication Biology. doi: 10.17912/micropub.biology.000410 (*co-corresponding author)

2020

Dehnen, L.*, Janz, M.*, Kumar Vermar, J., Psathaki, O.E., Langemeyer, L., Fröhlich, F., Heinisch, J.J., Meyer, H., Ungermann, C. and Paululat, A. (2020) A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function. Journal of Cell Science 133 (13): jcs.247080, doi: 10.1242/jcs.247080.

Beyenbach, K.W., Schöne, F., Breitsprecher, L.H., Tirbucy, F., Furuse, M., Izumi, Y., Meyer, H., Jonusaite, S., Rodan, A.R. and Paululat, A. (2020) The septate junction protein Tetraspanin 2A is critical to the structure and function of Malpighian tubules in Drosophila melanogaster. American Journal of Physiology - Cell Physiology. 318 (6): C1107-C1122, doi: 10.1152/ajpcell.00061.2020.

Jonusaite, S., Beyenbach, K.W., Meyer, H., Paululat, A., Izumi. Y., Furuse, M. and Rodan, A.R. (2020) The septate junction protein Mesh is required for epithelial morphogenesis, ion transport and paracellular permeability in the Drosophila Malpighian tubule. American Journal of Physiology - Cell Physiology 318 (3): C675-C694. doi: 10.1152/ajpcell.00492.2019.

2019

Schiemann, R., Lammers, K., Janz, M., Lohmann, J., Paululat, A. and Meyer, H. (2019) Identification and in vivo characterization of cardioactive peptides in Drosophila melanogaster. International Journal of Molecular Sciences (Int. J. Mol. Sci.) 20, 2 doi:10.3390/ijms20010002.

2018

Drechsler, M., Meyer, H., Wilmes, A. and Paululat, A. (2018) APC/CFzr regulates cardiac and myoblast cell numbers and plays a crucial role during myoblast fusion. Journal of Cell Science (JCS) 131(14), pii: jcs209155, doi: 10.1242/jcs.209155. This article is featured in the “Research Highlight” section of JCS.

Rotstein, B.*, Post, Y.*, Reinhardt, M., Lammers, K., Buhr, A., Heinisch, J.J., Meyer, H. and Paululat, A. (2018) Distinct domains present in the matricellular protein protein Lonely heart are crucial for cardiac extracellular matrix formation and heart function in Drosophila melanogaster. Journal of Biological Chemistry (JBC) (Epub ahead of print) DOI: 10.1074/jbc.M117.817940.

Wilmes, A.C., Klinke, N., Rotstein, B., Meyer, H. and Paululat, A. (2018) Biosynthesis and assembly of the Collagen IV-like protein Pericardin in Drosophila melanogaster. Biology Open 7 (4).     

Balcazar, D., Regge, V., Santalla, M., Meyer, H., Paululat, A., Mattiazzi, A. and Ferrero, P. (2018) SERCA is critical to control the Bowditch effect in the heart. Scientific Reports 8:12447. doi:10.1038/s41598-018-30638-9.

2017

     Lammers, K., Abeln, B., Hüsken, M., Lehmacher, C., Psathaki, O.E., Alcorta, E., Meyer, H. and Paululat, A. (2017) Formation and function of intracardiac valve cells in the Drosophila heart. Journal of Experimental Biology (JEB) 220 (10): 1852-1863.

     Purschke, G., Hugenschütt, M., Ohlmeyer, L., Meyer, H. and Weihrauch, D. (2017) Structural analysis of the branchiae and dorsal cirri in Eurythoe complanata (Annelida, Amphinomida). Zoomorphology 136: 1-18.

     Thiel, D., Hugenschütt, M., Meyer, H., Paululat, A., Quijada-Rodriguez, A., Purschke, G. and Weihrauch, D. (2017) Ammonia excretion in the marine polychaete Eurythoe complanata (Annelida) Journal of Experimental Biology 220: 425-436.

2016

     Hallier, B.*, Schiemann, R.*, Cordes, E., Vitos-Faleato, J., Walter, S., Heinisch, J.J., Malmendal, A., Paululat, A. and Meyer, H. (2016) Neprilysins control insulin signaling and food uptake via cleavage of regulatory peptides. eLIFE 2016,5:e19430

2015

     Hallier, B., Hoffmann, J., Roeder, T., Tögel, M., Meyer, H. and Paululat, A. (2015) The bHLH transcription factor Hand regulates the expression of genes critical to heart and muscle function in Drosophila melanogaster. PLOS One e0134204.

     Hüsken, M., Hufnagel, K., Mende, K., Appel, E, Meyer, H., Peisker, H, Tögel, M, Wang, S., Wolff, J., Gorb, S. and Paululat, A. (2015) Adhesive pad differentiation in Drosophila melanogaster depends on the Polycomb group gene Su(z)2. Journal of Experimental Biology 218: 1159-1165.

2014

     Moschner, K.*, Sündermann, F.*, Meyer, H., da Graca, A.P., Appel, N., Paululat, A., Bakota, L. and Brandt, R. (2014) RNA-protein granules modulate tau isoform expression and induce neuronal sprouting. Journal of Biological Chemistry 289 (24): 16814-16825.

2013

     Drechsler, M., Schmidt, A., Meyer, H. and Paululat, A. (2013) The conserved ADAMTS-like protein Lonely heart mediates matrix formation and cardiac tissue integrity. PLOS Genetics 9(7): e1003616. This work is featured by the Faculty of 1000 (http://f1000.com/prime/718063966)

     Tögel, M., Meyer, H., Heinisch, J.J., Lehmacher, C., Pass, G. and Paululat, A. (2013) The bHLH transcription factor Hand is required for proper wing heart formation in Drosophila. Developmental Biology 381(2): 446-459.

2012

     Panz, M. , Vitos-Faleato, J.V., Jendretzki, A., Heinisch, J., Paululat, A. and Meyer, H. (2012) A novel role for the non catalytic intracellular domain of Neprilysins in muscle physiology. Biol Cell 104: 553-568.

     Weihrauch, D., Chan, A., Meyer, H., Döring, C., Sourial, M., O´Donnell, M. (2012) Ammonia excretion in the freshwater planarian Schmidtea mediterranea. J Exp Biol 215: 3242-3253.

     Wang, S., Meyer, H., Ochoa-Espinosa, A., Buchwald, U., Önel, S., Altenhein, B., Heinisch, J., Affolter, M. and Paululat, A. (2012) GBF1 (Gartenzwerg)-dependent secretion is required for Drosophila tubulogenesis. J Cell Sci 125: 461-472.

2011

     Meyer, H., Panz, M., Albrecht, S., Drechsler, M., Wang, S., Hüsken, M., Lehmacher, C. and Paululat, A. (2011) Drosophila metalloproteases in development and differentiation: The role of ADAM proteins and their relatives. Eur J Cell Biol 90 (9): 770-778.

     Meyer, H., Vitavska, O. and Wieczorek, H. (2011). Identification of the first animal sucrose transporter. J Cell Sci 124: 1984-1991.

2010

     Meyer, H., Von Ohlen, T., Panz, M. and Paululat, A. (2010). The disintegrin and metalloprotease Meltrin from Drosophila forms oligomers via its protein binding domain and is regulated by the homeobox protein VND during embryonic development. Insect Biochem Mol Biol 40, 814-823.

     Blaesse, A. K., Broehan, G., Meyer, H., Merzendorfer, H. and Weihrauch, D. (2010). Ammonia uptake in Manduca sexta midgut is mediated by an amiloride sensitive cation/proton exchanger: Transport studies and mRNA expression analysis of NHE7, 9, NHE8, and V-ATPase (subunit D). Comp Biochem Physiol 157, 364-76.

2009

     Meyer, H., Panz, M., Zmojdzian, M., Jagla, K. and Paululat, A. (2009). Neprilysin 4, a novel endopeptidase from Drosophila melanogaster, displays distinct substrate specificities and exceptional solubility states. J Exp Biol 212, 3673-83.

     Piermarini, P. M., Weihrauch, D., Meyer, H., Huss, M. and Beyenbach, K. W. (2009). NHE8 is an intracellular cation/H+ exchanger in renal tubules of the yellow fever mosquito Aedes aegypti. Am J Physiol Renal Physiol 296, F730-50.

2004

     Meyer, H., Wieczorek, H. and Zeiske, W. (2004). K+ transport in the caterpillar intestine epithelium: role of osmolytes for the K+-secretory capacity of the tobacco hornworm midgut. J Comp Physiol B 174, 527-39.

2002

     Zeiske, W., Meyer, H. and Wieczorek, H. (2002). Insect midgut K(+) secretion: concerted run-down of apical/basolateral transporters with extra-/intracellular acidity. J Exp Biol 205, 463-74.

Publications

Heiko Harten, formerly Meyer